A Glimpse into the Past: The History of PGT

Preimplantation Genetic Testing (PGT), a cornerstone of modern reproductive medicine, has a fascinating history rooted in scientific curiosity and the desire to improve outcomes for aspiring parents. While the concept of understanding genetic health before implantation might seem like a recent innovation, its foundations were laid much earlier. The journey of PGT truly began to take shape in the late 20th century.

In 1990, a significant breakthrough occurred when Handyside et al. in the United Kingdom successfully used PGT to determine the sex of embryos for couples at risk of transmitting X-linked genetic disorders. This pioneering work marked the first practical application of PGT, then often referred to as Preimplantation Genetic Diagnosis (PGD). This initial success opened the door for further research and development into screening embryos for a wider range of genetic conditions.

Following this, Dr. Santiago Munne played a pivotal role in advancing PGT, particularly in the development of PGT for aneuploidy (PGT-A), which screens for chromosomal abnormalities. His contributions, along with those of many other dedicated researchers and clinicians, transformed PGT from an experimental procedure into a widely accepted and integral part of assisted reproductive technologies, offering hope and options to countless families worldwide. The evolution of PGT continues, driven by ongoing advancements in genetic science and reproductive medicine.